Houjun Liu


Rosetta is a set of physical-based protein folding models.

protein binding with Rosetta

  • check a protein surface
  • check how protein side-chains interact with the binding surface

peptide binding with Rosetta

The difficulty with this is that we don’t know what the overall tertiary structure of a group of peptides are; unlike whole protein binding.

sequence-specific DNA binding



You take something like a trimer; you shove a peptide between each “point”, and boom structal change to a quadromer