- traditional stain techniques to analyze the epitopes being targeted
- uses cyro-EM structural analysis to figure structural points of neutralization
- predict correct antibodies binding to force certain structures to neutralize covid-19
- analyze mRNA-vax elicited antibodies to see similarity between those that are useful predicted in 3)
Study identified three epitopes: C1520, C1791, C1717, which changes the structure/activity of all three variants of concern as identified using methods above, and are inpervious to the mutation to the main supersite.