Using a bunch of signals to create a 3d representation of the system

features

• cyro-EM
• x-ray
• tomo
• glynomics/libidomics
• genetics

studying large-scale viron surface protein behavior using MD

“we are so biased by what we can see experimentally, so do MD”

“breathing” motion

• proteins of specific virons “breath”: oning and closing an entire backbone group; this is not yet quantified in physical modeling
• when its open, the “breathing open” motion causes the virus to be vunerable
• so some antibodies jam into the open position

“head tilting” motion

• when its tilted, there is an epitope that becomes exposed
• this is a site that’s possible for introduction of what’s needed

overall architecture

• use conventional MD
• discover regions of instability (see above for examples) for possible binding surfaces
• bam inhibition!

maybe at some point run a cyro-EM to experimentally run some

Imperialism: a policy of extending a country’s power and influence though diplomacy or military force.

1. Colonies
2. Protectorate — nations has own government legally controlled by outside power
3. Sphere of influence

U.S. Imperialism, why?

1. “Desire for Military strength”: for a nation to be an international player, you have to have a strong navy
2. “Thirst for new markets”: if we continue to expand, we will have more economic power
3. “Belief in supernatural superiority”: trust that own culture is better

Alaska — “Seward’s Ice Box”, purchased from czarist Russia.

Key insight: suppose you have some fairly rare event and you want the likelihood of it. We can do this by drawing normal samples and reweighing them.

Suppose we want \(p_{\text{fail}}\); and we have \(q\) the proposal distribution and \(p\) the nominal distribution:

\(\tau \sim q\qty(\cdot)\), \(p_{\text{fail}} = \int 1 \qty {\tau \not\in \psi} p\qty(\tau) \dd{\tau }\)

What if we define a weird \(1\) such that:

\begin{equation} 1 = \frac{q\qty(\tau)}{q\qty(\tau)} \end{equation}

The Inbox is an Inbox for quick captures.

If an outcome can be from sets \(A=m\) or \(B=n\) with no overlaps, where \(A \cap B = \emptyset\), then, the total number of outcomes are \(|A| + |B| = m+n\)

If there are overlap:

\begin{equation} N = |A|+|B| - |A \cap B| \end{equation}